结合注意力的3D卷积网络脑胶质瘤分割算法

为了提升脑胶质瘤分割精度，提出一种结合注意力机制的3D卷积神经网络算法。输入3个不同尺度的图像块，经过9个卷积层和1个分类层后得到3个不同的分类结果，将分类结果与注意力学习到的权重相乘并逐体素相加得到输出。此外该算法采用了一种混合Dice损失函数与Focal损失函数的超参数损失函数。实验表明，该算法的Dice系数在整体区域、核心区域以及增强区域分别达到了95.31%、80.12%、82.25%。与已有的一种脑胶质瘤分割算法deepmedic相比，整体区域、核心区域以及增强区域的Dice系数分别提升了3%、2%、6%。在脑胶质瘤分割方面，具有重要的临床意义。     

面向噪声丢包感知的无线网络拥塞算法

针对无线网络链路干扰大、误码率高等特点，以及TCP Westwood算法（TCPW）存在估算带宽时过度依赖包的反馈，缺乏区分传输过程中丢包类型的缺点等问题，提出一种TCPW拥塞控制优化算法--TCPW-F。该算法利用发送速率等构建拥塞因子[F]作为判断丢包类型的依据，同时对判定发生噪声丢包时的拥塞窗口进一步调整，避免噪声丢包引起的窗口下降，提高该情况下窗口的发送效率。仿真结果表明，TCPW-F算法在时延性能方面表现更优，单位时间抖动趋于稳定的速度更快。在同一信道带宽下增大包生成速率，改进算法的实时吞吐量明显高于原算法，具备一定的噪声丢包感知能力，无线网络的TCP传输质量获得较大改善。     

Systematic convergence of nonlinear stochastic estimators on the Special Orthogonal Group SO(3)

This paper introduces two novel nonlinear stochastic attitude estimators developed on the Special Orthogonal Group with the tracking error of the normalized Euclidean distance meeting predefined transient and steady‐state characteristics. The tracking error is confined to initially start within a predetermined large set such that the transient performance is guaranteed to obey dynamically reducing boundaries and decrease smoothly and asymptotically to the origin in probability from almost any initial condition. The proposed estimators produce accurate attitude estimates with remarkable convergence properties using measurements obtained from low‐cost inertial measurement units. The estimators proposed in continuous form are complemented by their discrete versions for the implementation purposes. The simulation results illustrate the effectiveness and robustness of the proposed estimators against uncertain measurements and large initialization error, whether in continuous or discrete form.     

Computer‐aided design methodology for linearity enhancement of multiwatt GaN HEMT amplifiers using multiple parallel devices

This article presents a design methodology for linearizing GaN HEMT amplifiers based on splitting a large FET into multiple parallel FETs with same total gate periphery and by biasing them individually. By varying the biases, the magnitude and the phase of the IMD3 components at the output of FET changes. A detailed simulation methodology using commercial microwave CAD software is presented. Simulation results show that by biasing one device in Class AB and other(s) in deep Class AB mode, IMD3 components of parallel FETs can be made out of phase to each other leading to cancellation and improvement in linearity. Three prototype circuits were simulated using (a) a single 5 mm FET (1 × 5 mm), (b) two parallel 2.5 mm FETs (2 × 2.5 mm), and (c) four parallel 1.25 mm FETs (4 × 1.25 mm), for a total gate periphery of 5 mm, over the frequency range of 0.8 to 1.0 GHz. IMD3 improvement up to 20 dBc was achieved with the 4 × 1.25 mm circuit when the FET biases were optimized. Measurement results show improvement in linearity up to 20 dBc for 4 × 1.25 mm circuit. The proposed method improves linearity without a substantial penalty on the power consumption and is straightforward to implement.     

Modeling and design of 3-D MPPT for ultra low power RF energy harvesters

Radio-Frequency (RF) energy harvesting must cope with the limited availability and high variability of the energy source. In this paper, the modeling of an RF harvester for ultra low power environments is presented. A mathematical model based on theoretical analysis is developed. The model demonstrates that the maximum transferred power point is located in a three-dimensional space defined by the input capacitance, the output voltage, and the load resistance of the rectifier circuit. Moreover, the mathematical model returns results in substantial agreement with the SPICE simulation results, while guaranteeing a remarkable reduction of the required computation time. Furthermore, the paper reports the implementation of a mixed signal system for the 3-D MPPT, to be embedded in an RF harvester, in a 65 nm CMOS technology. The circuit exhibits a simulated power consumption lower than 100 nW, making this solution suitable for ultra low power harvesting.     

The alginate fermentation strain Pantoea sp. F16-PCAi-T3P21 and ethanol production

Bio-ethanol production from algae is a promising way to help solve the energy problem. Alginate is a major component of algae, but it cannot be utilized by existing ethanol fermentation microorganisms. In order to improve the utilization rate of brown algae, high alginate fermentation strains should be obtained. In this research, strains for algae fermentation were got from several experiments. The ethanol yield of strain A was the highest, which was 0.095 g/g (ethanol to alginate). The identification of strain A was carried out and it was 99% identical to Pantoea sp. F16-PCAi-T3P21. Fermentation experiments with different substrates were carried out, such as laminaran, mannitol, L. japonica and acid hydrolysate of L. japonica, and the ethanol yield rate of L. japonica acid hydrolysate was the highest, which reached 0.17 g/g ethanol to L. japonica. It showed that strain A can converse alginate to ethanol in a relatively high yield rate, and might be a promising strain with L. japonica as the substrate, we believe more research should be carried out on this strain.     

Retention of Eucalyptol,a Natural Volatile Insecticide,in Delivery Systems Based on Hydroxypropyl‐β‐Cyclodextrin and Liposomes

Eucalyptol (Euc) is a natural monoterpene with insecticide effects. Being highly volatile and sensitive to ambient conditions, its encapsulation would enlarge its application. Euc‐loaded conventional liposomes (CL), cyclodextrin/drug inclusion complex, and drug‐in‐cyclodextrin‐in‐liposomes (DCL) are prepared to protect Euc from degradation, reduce its evaporation, and provide its controlled release. The liposomal suspension is freeze‐dried using hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD) as cryoprotectant. The liposomes are characterized before and after freeze‐drying. The effect of Euc on the fluidity of liposomal membrane is also examined. A release study of Euc from delivery systems, in powder and reconstituted forms, is performed by multiple head extraction at 60 °C after 6 months of storage at 4 °C. CL and DCL suspensions are homogeneous, show nanometric vesicles size, spherical shape, and negative surface charge before and after freeze‐drying. Moreover, HP‐β‐CD does not affect the fluidity of liposomes. CL formulations present a weak encapsulation for Euc. The loading capacity of eucalyptol in DCL is 38 times higher than that in CL formulation. In addition, freeze‐dried DCL and HP‐β‐CD/Euc inclusion complex show a higher retention of eucalyptol than CL delivery system. Both carrier systems HP‐β‐CD/Euc and Euc‐loaded DCL decrease Euc evaporation and improve its retention. Practical Applications: Eucalyptol is a natural insecticide. It is highly volatile and poorly soluble in water. To enlarge its application, its encapsulation in three delivery systems (conventional liposomes, cyclodextrin/drug inclusion complex, combined system composed of cyclodextrin inclusion complex and liposome) is studied. In this paper it is proved that cyclodextrin/eucalyptol inclusion complex and eucalyptol‐in‐cyclodextrin‐in‐liposome are effective delivery systems for encalyptol encapsulation, retention, and release.     

聚乙烯醇/牛I型胶原支架材料的制备及评价

研究了一种聚乙烯醇(PVA)和胶原(COL)复合支架材料的制备方法。采用氨基硅烷对PVA海绵表面进行了氨基化修饰后，通过戊二醛溶液交联牛Ⅰ型胶原(COL)，最后通过赖氨酸溶液封闭，获得一种PVA/COL复合支架材料。采用扫描电镜(SEM)、X光电子能谱仪(XPS)、傅里叶红外光谱(FT-IR)等手段对支架材料的理化性能进行表征，并通过细胞实验对支架材料的生物学性能进行评价。结果表明，经过COL修饰的PVA孔隙率为21.33%，平均孔径为168.68 ?m且均匀分布，支架材料接触角为20.03°。对支架材料的生物学评价结果表明C3A细胞在复合材料上黏附良好，优于PVA组；CCK-8增殖检测结果表明细胞在复合材料上呈增殖生长趋势，与对照组PVA相比差异显著(P?0.01)。将PVA和COL复合制备得到的支架材料具有良好的理化及生物学特性，具有广阔的应用前景。